hnRNP RNA Processing
Gene co-expression module in Natural Killer cells
| Category | RNA processing & translation |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Three hnRNP proteins (HNRNPAB, HNRNPA2B1, HNRNPA3) are core RNA-binding proteins involved in mRNA processing, splicing, and export. CBX3 (HP1γ) is a chromatin-associated protein that also regulates RNA processing. RAN is a GTPase essential for nuclear-cytoplasmic transport of RNA and proteins. YWHAE (14-3-3ε) regulates numerous signaling pathways including RNA processing factors. GNG5 (G-protein γ5) and SLC25A5 (ANT2, mitochondrial ADP/ATP transporter) are peripheral members with weaker membership. The hnRNP triad with RAN and CBX3 defines an RNA processing/nuclear export program.
Genes
CBX3, GNG5, HNRNPA2B1, HNRNPA3, HNRNPAB, RAN, SLC25A5, YWHAE
Most correlated modules
- Oxidative Stress Response · correlation 0.89
- Metabolic Activation · correlation 0.87
- S/G2M Cell Cycle · correlation 0.84
- Glycolytic Metabolism · correlation 0.82
- Chromatin Remodeling · correlation 0.80
- Actin Cytoskeleton Remodeling · correlation 0.77
- Immunoproteasome Activation · correlation 0.75
- NK Cytotoxic Activation · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.