NK/ILC Differentiation
Gene co-expression module in Natural Killer cells
| Category | Differentiation |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
ZBTB16 (PLZF) is the master transcription factor for innate lymphocyte identity and ILC/NK cell differentiation. PIM2 is a pro-survival kinase downstream of cytokine signaling in NK cells. CHPT1 and CHKA encode choline phosphotransferase and choline kinase involved in phospholipid biosynthesis during lymphocyte activation/differentiation. PITPNC1 transfers phosphatidylinositol, relevant to PI3K signaling in NK differentiation. ARHGAP9 regulates Rho GTPases in lymphocyte migration/differentiation. STAM is involved in cytokine receptor signaling. Upregulated in CD inflammation. This module reflects NK/ILC differentiation and survival signaling.
Genes
ARHGAP9, CHKA, CHPT1, PIM2, PITPNC1, PPP1R16B, STAM, ZBTB16
Most correlated modules
- NK Cytotoxic Signaling · correlation 0.74
- NK Checkpoint Receptors · correlation 0.68
- Gut-Homing NK · correlation 0.65
- Inflammatory Stress Response · correlation 0.64
- Glucocorticoid Response · correlation 0.61
- Hypoxia Response · correlation 0.59
- Tissue-Resident NK · correlation 0.59
- Mature NK Identity · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.