Gut-Homing NK
Gene co-expression module in Natural Killer cells
| Category | Gut residency |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
CCR9 is the definitive gut-homing chemokine receptor directing lymphocytes to the small intestine via CCL25. TRAT1 is associated with lymphocyte signaling. PRKAR2B modulates cAMP/PKA signaling relevant to chemokine receptor function. SNX9 participates in receptor endosomal trafficking. PLPP1 modulates lipid phosphate signaling. The module is uniformly low-expressed, consistent with a gut-homing NK subset. Neighbor M85 (tissue-resident NK) supports a gut-homing/residency neighborhood.
Genes
CCR9, FAM3C, GRAMD2B, OXNAD1, PLPP1, PRKAR2B, SMIM3, SNX9, TRAT1
Most correlated modules
- Tissue-Resident NK · correlation 0.88
- NK Checkpoint Receptors · correlation 0.87
- NK Tissue Residency · correlation 0.78
- Resident NK program · correlation 0.76
- Resident NK cells · correlation 0.73
- Hypoxia Response · correlation 0.73
- NK Cytoskeletal Activation · correlation 0.69
- NK/ILC Differentiation · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.