Glucocorticoid Response
Gene co-expression module in Natural Killer cells
| Category | Immune regulation |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include SARAF (store-operated calcium entry associated regulatory factor, inhibits SOCE/CRAC channels), ELL2 (RNA polymerase II elongation factor, regulates transcription elongation), ELF1 (ETS transcription factor, NK/T cell gene regulation), SEC14L1 (lipid transfer protein), TSC22D3 (GILZ, glucocorticoid-induced leucine zipper, anti-inflammatory transcription factor), BCLAF1 (BCL2-associated transcription factor, apoptosis/splicing), GABARAPL1 (autophagy receptor), LEPROTL1 (leptin receptor overlapping transcript-like), BEX4 (brain expressed X-linked), ARF6 (ADP-ribosylation factor 6, vesicle trafficking), EPC1 (chromatin remodeling), PNRC1 (proline-rich nuclear receptor coactivator), ZFP36L2 (mRNA decay, AU-rich element binding), PFKFB3 (glycolysis regulator), BEX2, IDS (iduronate 2-sulfatase), PPP2CA (protein phosphatase 2A), AREG (amphiregulin, EGFR ligand), SON (splicing), TSPYL2. TSC22D3/GILZ is a canonical glucocorticoid response gene and anti-inflammatory regulator. SARAF regulates calcium signaling. ZFP36L2 promotes mRNA decay of inflammatory transcripts. PFKFB3 links to metabolic reprogramming. AREG is an immunoregulatory growth factor. The module is upregulated in CD inflammation but suppressed by CD treatment, consistent with a glucocorticoid/anti-inflammatory response program.
Genes
AREG, ARF6, BCLAF1, BEX2, BEX4, ELF1, ELL2, EPC1, GABARAPL1, IDS, LEPROTL1, PFKFB3, PNRC1, PPP2CA, SARAF, SEC14L1, SON, TSC22D3, TSPYL2, ZFP36L2
Most correlated modules
- TGF-β Antagonism · correlation 0.80
- Circadian NF-κB Crosstalk · correlation 0.75
- MAPK/AP-1 Signaling · correlation 0.75
- NK Immune Checkpoint · correlation 0.71
- NF-κB Activation · correlation 0.64
- NK/ILC Differentiation · correlation 0.61
- Autophagy-Inflammation Stress · correlation 0.60
- NK Cytotoxic Signaling · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.