PITPNC1 — Phosphatidylinositol transfer protein cytoplasmic 1
PITPNC1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PITPNC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Lipid Signaling migration & adhesion | A2M, ADGRG1, ARHGEF15, CNOT6L, CYYR1, DIP2B, HIP1R, PCDH1 +3 more | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2 +15 more | |
| Macrophages | PI3K Lipid Signaling Innate immunity | AGPAT4, AREG, DHX34, DNMBP, EEPD1, HIP1, IP6K1, IRAK2 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | CHST11, HDAC9, MGAT5, NCAM1, NCOA2, RASA2, SSH2 | |
| Natural Killer cells | NK/ILC Differentiation Differentiation | ARHGAP9, CHKA, CHPT1, PIM2, PPP1R16B, STAM, ZBTB16 | View in SCUBA |
| Pericytes | Vascular Pericyte Identity Developmental | ABCG1, ACVRL1, ATP11A, CASP10, CCM2L, CD320, GPRC5B, KL +7 more | View in SCUBA |
About the gene
| Synonyms | RDGB-BETA, RDGBB, RDGBB1 |
|---|---|
| Chromosome | 17: 67377281-67697256 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes. Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species. Catalyzes the transfer of phosphatidylinositol between membranes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.