NK Maturation Program
Gene co-expression module in Natural Killer cells
| Category | Differentiation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
EOMES is a T-box transcription factor and master regulator of NK cell maturation, cytotoxicity gene expression, and effector function. TOX2 is a transcription factor required for NK cell development and terminal differentiation. SH2D1A (SAP) is critical for NK and NKT cell signaling and cytotoxicity. BAALC is expressed in NK and myeloid progenitors. Together EOMES+TOX2+SH2D1A form a transcription factor triad for NK maturation. PDLIM1 and ARPC5L contribute cytoskeletal remodeling during NK differentiation. Upregulated in CD inflammation and suppressed by CD treatment, suggesting this reflects a mature NK effector differentiation state expanded in Crohn's disease.
Genes
ARPC5L, BAALC, CDHR1, EOMES, PDE7A, PDLIM1, S100PBP, SH2D1A, TESC, TOX2, YWHAH
Most correlated modules
- NK Homeostatic Survival · correlation 0.53
- NK TGF-β Regulation · correlation 0.49
- NK Lymphocyte Survival · correlation 0.48
- Inducible HSP70 Stress · correlation 0.34
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.