NK Lymphocyte Survival
Gene co-expression module in Natural Killer cells
| Category | Immune regulation |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
GIMAP7, GIMAP4, and GIMAP1 are GTPase immune-associated proteins critical for lymphocyte survival and homeostasis, strongly expressed in NK and T cells. TRAF3IP3 (TRAF3-interacting protein 3) modulates innate immune signaling. SLAMF6 is an NK/T cell co-receptor involved in NK cell activation. FGR is a Src-family kinase active in NK cells. IL16 is a lymphocyte chemoattractant. PTGDR (prostaglandin D2 receptor) modulates NK cell migration. The GIMAP cluster dominates this module, pointing to NK lymphocyte survival/homeostasis. Upregulated in CD inflammation, consistent with NK cell accumulation or survival in inflamed intestine.
Genes
DENND2D, FGR, GIMAP1, GIMAP4, GIMAP7, IL16, PTGDR, SLAMF6, TRAF3IP3
Most correlated modules
- NK TGF-β Regulation · correlation 0.72
- NK Homeostatic Survival · correlation 0.56
- Cytoskeletal Remodeling · correlation 0.54
- IFN-stimulated NK · correlation 0.49
- NK Maturation Program · correlation 0.48
- NK Cell Identity · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.