NK Homeostatic Survival
Gene co-expression module in Natural Killer cells
| Category | Immune regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
SLFN5 (Schlafen 5) is an interferon-inducible gene involved in immune cell quiescence and antiviral defense, highly expressed in NK and T cells. GIMAP6 is a GTPase of the immunity-associated protein family critical for lymphocyte survival and homeostasis. FYB1 (FYN-binding protein) is a T/NK cell signaling adaptor involved in integrin-mediated activation. ACAP1 is an ARF GAP involved in endosomal recycling and lymphocyte trafficking. GPR174 is a lysophosphatidylserine receptor expressed on lymphocytes regulating migration. IRF2 is a transcription factor that represses interferon responses and regulates NK cell development. SYNRG is a synergin involved in vesicle trafficking. STOM (stomatin) is a lipid raft protein. ARHGAP30 is a Rho GAP expressed in immune cells. CAPN12 is a calpain protease. The strong CD inflammation signal (delta_inflammation_CD = 1.825 sig.) and the presence of SLFN5, GIMAP6, FYB1, IRF2, and GPR174 point to a lymphocyte identity/quiescence-to-activation transition program, consistent with NK cell tissue residency or homeostatic survival in the inflamed intestine.
Genes
ACAP1, ARHGAP30, CAPN12, FYB1, GIMAP6, GPR174, IRF2, SLFN5, STOM, SYNRG
Most correlated modules
- NK Inflammatory Activation · correlation 0.76
- Cellular Homeostasis · correlation 0.70
- ILC1/NK Cytotoxic · correlation 0.69
- NK Cell Activation · correlation 0.65
- IFN-stimulated NK · correlation 0.65
- Mature NK Identity · correlation 0.64
- NK Cytotoxic Signaling · correlation 0.59
- NK Lymphocyte Survival · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.