TOX2 — TOX high mobility group box family member 2
TOX2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TOX2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh program B cell help | BAZ2B, CCDC50, CDK5R1, CXCR5, IL6R, LY96, MTUS1, PASK +10 more | View in SCUBA |
| Endothelial | Arterial EC Identity Endothelial cell development | ABR, AIF1L, ASS1, CCDC88C, CPNE8, EPHA4, IFITM2, MOB2 +5 more | View in SCUBA |
| Hematopoietic progenitor cells | ILC3/γδT Priming Lymphcyte development | C2CD4D, CCL1, CCR1, CD2, CD7, CHI3L2, FGR, GPR18 +8 more | |
| Innate lymphoid cells | Transcriptional Regulation DNA regulation & transcription | ACAA1, ATRX, C1orf43, CARHSP1, CHTOP, CTDSP1, CTR9, DRAP1 +18 more | View in SCUBA |
| Natural Killer cells | NK Maturation Program Differentiation | ARPC5L, BAALC, CDHR1, EOMES, PDE7A, PDLIM1, S100PBP, SH2D1A +2 more | View in SCUBA |
About the gene
| Synonyms | C20orf100, dJ1108D11.2, GCX-1 |
|---|---|
| Chromosome | 20: 43914852-44069616 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.