SCUBA

YWHAH — Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta

YWHAH belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

YWHAH's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsEffector Immune Activation
Immune regulation
ABI3, APBB1IP, ASB2, BUB3, CALCOCO2, CASP4, COMMD7, CTSD +7 moreView in SCUBA
CD8⁺ T cellsGeneral Housekeeping
Housekeeping
ANAPC11, ANP32B, ARPC5, BANF1, CALM3, CARHSP1, COX8A, HMGN1 +5 moreView in SCUBA
EndothelialIntegrin-Actin Adhesion
migration & adhesion
APP, CHD3, CTNNA1, DAG1, DOCK6, FKBP9, FMNL3, ITGA9 +6 moreView in SCUBA
Glial cellsER Membrane Homeostasis
Neroprotection
GNAI2, KHDRBS3, LITAF, RTN4, SARAF, SBDS, SH3BGRL, SNCA +1 moreView in SCUBA
Goblet cellsSpliceosome Assembly
RNA processing & translation
ALYREF, ANAPC11, BANF1, LSM4, MRPL51, PPIH, PTBP1, RAN +8 moreView in SCUBA
Innate lymphoid cellsILC Identity Program
Differentiation
AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 moreView in SCUBA
Mucosal-associated invariant T cellCellular Housekeeping
Housekeeping
ABI3, AP2M1, CD151, CD2, CKLF, DYNLL1, FDFT1, LRP10 +7 more
Natural Killer cellsNK Maturation Program
Differentiation
ARPC5L, BAALC, CDHR1, EOMES, PDE7A, PDLIM1, S100PBP, SH2D1A +2 moreView in SCUBA
Smooth muscle cellsActin Dynamics Housekeeping
Housekeeping
C12orf75, CAPZA2, CFL1, ELN, ENY2, PPIA, PRDX1, PSMB1 +3 moreView in SCUBA

About the gene

SynonymsYWHA1
Chromosome22: 31944522-31957603
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Plasma proteins, Predicted intracellular proteins

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.