NK Activation Signaling
Gene co-expression module in Natural Killer cells
| Category | activation |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
ZAP70 is a key kinase in NK cell activation signaling downstream of activating receptors. RASA3 is a RAS-GAP that regulates integrin activation in NK cells. ZYX (zyxin) and SLC44A2 are expressed in NK cells and involved in adhesion and membrane function respectively. PSAP (prosaposin) is a lysosomal protein relevant to granule biology. SUN2 (LINC complex) links cytoskeleton to nucleus during immune synapse formation. PLSCR3 (phospholipid scramblase) participates in membrane remodeling during activation. Significantly upregulated in CD inflammation. This module reflects NK cell activation signaling and cytoskeletal reorganization.
Genes
CEP78, PLSCR3, PSAP, RASA3, SLC44A2, SUN2, ZAP70, ZYX
Most correlated modules
- NK Degranulation Activation · correlation 0.89
- Cytotoxic NK Maturation · correlation 0.86
- NK Activation Signaling · correlation 0.78
- KIR+ NK Maturation · correlation 0.76
- NK Homing Adhesion · correlation 0.75
- Interferon NK Activation · correlation 0.73
- Cytoskeletal Remodeling · correlation 0.66
- Innate Sensing NK Regulation · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.