NK Degranulation Activation
Gene co-expression module in Natural Killer cells
| Category | activation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
SELPLG (PSGL-1) mediates leukocyte rolling and homing. RASGRP2 activates integrins for firm adhesion. SYTL1 (synaptotagmin-like 1) regulates lytic granule trafficking and NK degranulation. STING1 mediates innate immune sensing of cytosolic DNA. TFEB drives lysosomal biogenesis relevant to granule maintenance. BIN2 regulates membrane dynamics. PXN (paxillin) and STK38 link to cytoskeletal signaling. The module is upregulated in both UC and CD inflammation. The combination of granule trafficking (SYTL1), innate sensing (STING1), and adhesion/homing (SELPLG, RASGRP2) suggests NK cell activation with degranulation readiness and innate sensing.
Genes
BIN2, CCND3, GPR141, OSBPL5, PXN, RASGRP2, SELPLG, SH3BP5, STING1, STK38, SYTL1, TFEB
Most correlated modules
- Cytotoxic NK Maturation · correlation 0.91
- NK Activation Signaling · correlation 0.89
- NK Activation Signaling · correlation 0.84
- NK Homing & Residency · correlation 0.80
- NK Homing Adhesion · correlation 0.76
- KIR+ NK Maturation · correlation 0.75
- Cytoskeletal Remodeling · correlation 0.73
- Granulysin Cytotoxic Effector · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.