Actin Cytoskeleton Remodeling
Gene co-expression module in Natural Killer cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes ARPC1B, ARPC4, CAPZB, WDR1, PFN1, and RAC2 are all core regulators of actin cytoskeleton dynamics — Arp2/3 complex subunits, actin capping proteins, profilin, and cofilin activator WDR1. PPP1CA (PP1 phosphatase) regulates actin-myosin. CAPNS1 is the calpain small subunit involved in cytoskeletal remodeling. This module is tightly focused on actin polymerization and remodeling machinery. Upregulated in CD inflammation and reduced with treatment, consistent with active NK cell migration and cytoskeletal reorganization in inflamed intestine. Neighbor modules M28 and M2 share the same disease trajectory, supporting a coordinated NK activation program.
Genes
ANXA6, ARPC1B, ARPC4, BAX, CAPNS1, CAPZB, GNAI2, IL2RG, NDUFA13, NUCB1, PFN1, PPP1CA, PTPN18, RAB1B, RAC2, WDR1
Most correlated modules
- Energy Metabolism · correlation 0.77
- NK Cytotoxic Activation · correlation 0.68
- Histone Variant Remodeling · correlation 0.68
- Gut-Homing NK Maturation · correlation 0.64
- Immunoproteasome Activation · correlation 0.63
- NK Activation Signaling · correlation 0.59
- NK Homing Adhesion · correlation 0.56
- NK TGF-β Regulation · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.