PXN — Paxillin
PXN belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PXN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Lymphatic Valve Development Valve formation | GPM6A, LRP5, MEF2C, MPP7, NFIA, NFIB, PGM5, PRKAR1B +5 more | View in SCUBA |
| Monocytes | Granulocytic Differentiation Developmental | CSF3R, GLT1D1, HEBP2, NDUFB9, NRGN, PLP2, PNPLA2, SMARCD3 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Remodeling Migration migration & adhesion | ADAM8, BIN2, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2 +14 more | |
| Natural Killer cells | NK Degranulation Activation activation | BIN2, CCND3, GPR141, OSBPL5, RASGRP2, SELPLG, SH3BP5, STING1 +3 more | View in SCUBA |
| Neutrophils | Mature Neutrophil Identity Developmental | ALPL, CR1, CRISPLD2, IL4R, NIBAN1, SH3GLB1, ST3GAL4 |
About the gene
| Chromosome | 12: 120210439-120265771 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell adhesion |
Function
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.