NK Homing & Residency
Gene co-expression module in Natural Killer cells
| Category | Homing & TEM |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
TPST2 (sulfation of chemokine receptors enabling homing), S1PR4 (sphingosine-1-phosphate receptor controlling lymphocyte trafficking), RIPOR2 (cell polarization/migration), CD47 (anti-phagocytic signal supporting tissue residency), CTSW (NK/CTL-specific cathepsin), TSPAN32 (NK cell tetraspanin), and FXYD5 (cell adhesion modulator) collectively point to NK cell tissue homing, migration, and gut residency. Upregulated significantly in both UC and CD inflammation, consistent with NK cell recruitment and retention in inflamed intestine.
Genes
C11orf21, CD47, CTSW, FXYD5, PRMT2, RIPOR2, S1PR4, SAMHD1, TFDP2, TPST2, TSPAN32
Most correlated modules
- NK Homing Adhesion · correlation 0.80
- Granulysin Cytotoxic Effector · correlation 0.80
- NK Degranulation Activation · correlation 0.80
- NK Activation Signaling · correlation 0.79
- Cytotoxic NK Maturation · correlation 0.74
- Innate Sensing NK Regulation · correlation 0.73
- NK Cell Activation · correlation 0.70
- Cytoskeletal Remodeling · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.