RASGRP2 — RAS guanyl releasing protein 2

RASGRP2 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RASGRP2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	B cell activation signaling B cell maturation	ANKRD44, BLK, BTN3A2, EVI2B, GAPT, GPSM3, LBH, LTB +9 more	View in SCUBA
CD4⁺ T cells	Naive T quiescence T cell development	CCR7, CD55, CRIP2, CSGALNACT1, ITGA6, KLF2, KLF3, NOSIP +6 more	View in SCUBA
CD8⁺ T cells	Naive/Central Memory T cell maturation	AIF1, ATM, CCR7, FCMR, FOXP1, KLF2, KLF3, LDLRAP1 +7 more	View in SCUBA
Fibroblasts	ICC niche interactaion Gut motility	ABCC9, ADGRF5, ANO1, CD36, CFHR1, ESAM, FHL5, HOPX +10 more	View in SCUBA
Gamma-delta T cells	TCR Proximal Signaling TCR Signaling	ADGRG5, BIN2, C11orf21, C12orf75, CD300A, FGR, GPSM3, LAT +11 more
Innate lymphoid cells	ILC3 identity Differentiation	ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more	View in SCUBA
Mucosal-associated invariant T cell	Cytotoxic Effector cytotoxicity	ANXA4, CCM2, CD320, CST7, DYNLRB1, GZMM, LIMD2, MCUB +10 more
Natural Killer cells	NK Degranulation Activation activation	BIN2, CCND3, GPR141, OSBPL5, PXN, SELPLG, SH3BP5, STING1 +3 more	View in SCUBA
Pericytes	Pericyte Vascular Tone Developmental	ADAP2, CHCHD10, CSPG4, FOXS1, LINGO1, MCAM, MFGE8, PGF +3 more	View in SCUBA

About the gene

Synonyms	CALDAG-GEFI
Chromosome	11: 64726911-64745456
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Molecular function	Guanine-nucleotide releasing factor

Function

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.