NK Activation Signaling
Gene co-expression module in Natural Killer cells
| Category | activation |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
All genes show core membership in a highly coherent module. LIME1 (Lck-interacting membrane protein, NK/T cell activation scaffold), GRAP2 (GRB2-related adaptor linking TCR/NK receptors to downstream signaling), RGS9 (G-protein signaling modulator), GZMH (granzyme H, cytotoxic effector), SYT11 (synaptotagmin-11, vesicle fusion/degranulation), and F2R (PAR1, inflammatory GPCR) together define an NK cell activation and degranulation signaling program. Significantly upregulated in both UC and CD inflammation, reversed in remission, consistent with inflammatory NK cell activation in IBD.
Genes
C12orf75, F2R, GRAP2, GZMH, LIME1, LYAR, RGS9, SSBP3, SYT11, TTC16
Most correlated modules
- Cytotoxic NK Maturation · correlation 0.86
- NK Degranulation Activation · correlation 0.84
- Granulysin Cytotoxic Effector · correlation 0.81
- NK Homing & Residency · correlation 0.79
- NK Activation Signaling · correlation 0.78
- NK Homing Adhesion · correlation 0.73
- KIR+ NK Maturation · correlation 0.72
- Innate Sensing NK Regulation · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.