Cytoskeletal Remodeling
Gene co-expression module in Natural Killer cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes PRKCB, ADD3, ARHGAP25, CAPN2, MYO1F, MYO1G, DGKZ, CYTH1, and ARHGEF3 collectively encode a cytoskeletal remodeling and actin dynamics program. Myosins (MYO1F/MYO1G), Rho GTPase regulators (ARHGAP25, ARHGEF3), adducin (ADD3), calpain-2 (CAPN2), and cytohesin-1 (CYTH1, integrin activation) all participate in NK cell polarization, migration, and immune synapse formation. Neighbor to M67 (which contains CAST, the calpain inhibitor), reinforcing shared cytoskeletal regulation. Upregulated in CD inflammation.
Genes
ADD3, ARHGAP25, ARHGEF3, C1orf21, CAPN2, CYTH1, DGKZ, DIP2A, GBP5, MYO1F, MYO1G, PRKCB, PTPN4
Most correlated modules
- Cytotoxic NK Maturation · correlation 0.75
- NK Degranulation Activation · correlation 0.73
- NK Homing Adhesion · correlation 0.72
- NK Activation Signaling · correlation 0.70
- NK Homing & Residency · correlation 0.70
- Innate Sensing NK Regulation · correlation 0.70
- NK Cell Maturation · correlation 0.66
- NK Activation Signaling · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.