S1PR4 — Sphingosine-1-phosphate receptor 4
S1PR4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
S1PR4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation signaling B cell maturation | ANKRD44, BLK, BTN3A2, EVI2B, GAPT, GPSM3, LBH, LTB +9 more | View in SCUBA |
| Gamma-delta T cells | Effector IFN Response cytotoxicity | AGTRAP, ANXA1, B2M, CYBA, EMP3, FXYD5, GZMM, IFITM1 +9 more | |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACAP2, APBB1IP, ARHGAP25, ATM, CD247, CHD9, CLCN3, DDX17 +14 more | |
| Natural Killer cells | NK Homing & Residency Homing & TEM | C11orf21, CD47, CTSW, FXYD5, PRMT2, RIPOR2, SAMHD1, TFDP2 +2 more | View in SCUBA |
| Neutrophils | Neutrophil Differentiation Developmental | ABTB1, FRAT2, GCA, ICAM3, MANSC1, MNDA, MSL3, NFE2 +2 more |
About the gene
| Synonyms | EDG6 |
|---|---|
| Chromosome | 19: 3172346-3180332 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.