SLC44A2 — Solute carrier family 44 member 2
SLC44A2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC44A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitophagy Stress Response Stress | C1QTNF12, CDA, CPNE2, FAM219A, FCN3, GSDMC, IGFBP3, INSR +7 more | View in SCUBA |
| Gamma-delta T cells | Innate Stress Signaling Inflammation | AKT3, B4GALT4, BCR, BLOC1S4, COL6A2, CREBRF, DGKQ, ELF2 +23 more | |
| Lymphatic endothelial | Innate Immune Activation Immune regulation | CD46, CLTC, CRIM1, EIF2AK2, ENSA, FEZ2, GSN, PDLIM3 +9 more | View in SCUBA |
| Natural Killer cells | NK Activation Signaling activation | CEP78, PLSCR3, PSAP, RASA3, SUN2, ZAP70, ZYX | View in SCUBA |
| Pericytes | Vascular Junction Adhesion Migration & adhesion | ABHD17A, CCDC85B, CDC37, ESAM, FYN, HECW2, PREX1, SELENON +2 more | View in SCUBA |
About the gene
| Synonyms | CTL2 |
|---|---|
| Chromosome | 19: 10602457-10644557 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Antiport, Transport |
Function
Choline/H+ antiporter, mainly in mitochodria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway. Does not exhibit choline transporter activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.