Calcium Handling Contractile
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 3 of 8 genes have a known function matching the annotation |
Why this annotation
Very highly expressed, near-ubiquitously detected module combining smooth-muscle calcium-handling/contractile regulators (PLN, phospholamban — a canonical visceral SMC SERCA inhibitor; CALM2, calmodulin, the MLCK activator; HSPB1/HSP27, an actin-cytoskeleton chaperone that regulates SMC contraction) with abundant translation/respiration transcripts (YBX1, EIF4A2, COX7A2, UQCRB, PPDPF). The contractile-calcium genes are the biologically informative core; the remaining genes reflect the general high-abundance axis shared with neighbors M86/M48/M101. Interpreted as a mature contractile SMC state module.
Genes
CALM2, COX7A2, EIF4A2, HSPB1, PLN, PPDPF, UQCRB, YBX1
Most correlated modules
- SMC contractile apparatus · correlation 0.86
- OxPhos & proteasome · correlation 0.85
- Basal Maintenance Genes · correlation 0.84
- Translation elongation housekeeping · correlation 0.84
- Post-translational regulators · correlation 0.80
- Myogenic Cytoskeletal Program · correlation 0.80
- OxPhos & Translation · correlation 0.78
- Glucocorticoid Metallothionein Response · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.