PLN — Phospholamban
PLN belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Smooth Muscle Identity Cytoskeletal | ACTG2, ALDH1B1, C3orf70, CNN1, FBXL22, HSD17B6, JPH2, KCNH2 +12 more | View in SCUBA |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | GPRC5C, MYH11, NET1, NRGN, PALLD, RERGL, SYNE1, SYNM +2 more | View in SCUBA |
| Smooth muscle cells | Calcium Handling Contractile Contractility | CALM2, COX7A2, EIF4A2, HSPB1, PPDPF, UQCRB, YBX1 | View in SCUBA |
About the gene
| Synonyms | CMD1P, PLB |
|---|---|
| Chromosome | 6: 118548296-118561716 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
Function
Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Binds preferentially to the ATP- bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation (By similarity). In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.