SMC contractile apparatus
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Textbook smooth muscle contractile apparatus module: MYL9, ACTA2, TAGLN, TPM2, MYL6, CALD1 plus the myosin-phosphatase inhibitor PPP1R14A (CPI-17) that mediates Ca2+ sensitization, with actin-dynamics partners DSTN and ACTB and caveolar CAV1 (which organizes contractile signalling in SMCs). Core coherence and near-universal detection indicate this is the identity/differentiation program of the colonic smooth muscle cells themselves, not contamination. As a neighbor of the housekeeping module M122, its correlation is partly driven by shared abundance, but the gene content is unambiguously contractile.
Genes
ACTA2, ACTB, CALD1, CAV1, DSTN, MYL6, MYL9, PPP1R14A, SH3BGRL, TAGLN, TPM2
Most correlated modules
- Calcium Handling Contractile · correlation 0.86
- OxPhos & proteasome · correlation 0.85
- Translation elongation housekeeping · correlation 0.83
- OxPhos & Translation · correlation 0.78
- Respiratory Chain Subunits · correlation 0.76
- Basal Maintenance Genes · correlation 0.75
- SMC Contractile Apparatus · correlation 0.73
- Rho GTPase Housekeeping · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.