Post-translational regulators
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hubs are small ubiquitous regulators of protein fate and nuclear architecture: PIN1 (prolyl isomerase), SUMO1, BAG1 (HSP70 co-chaperone), TBCA (tubulin chaperone), ERH, BANF1, HMGN3, SAP-like chromatin factors, together with a calcium-signaling arm (SMDT1/EMRE, CALM3, ANXA11, CAMTA1). No single pathway dominates and memberships are strong but the program is generic, indicating a broadly co-varying post-translational/nuclear maintenance module rather than a stimulus-driven state. Fits the housekeeping-rich neighborhood (M115, M123, M110).
Genes
ANXA11, BAG1, BANF1, CALM3, CAMTA1, ERH, HMGN3, MYO1C, NENF, PIN1, RAP1A, SMDT1, SUMO1, TBCA, ZFYVE21
Most correlated modules
- OxPhos & proteasome · correlation 0.91
- Generic maintenance transcripts · correlation 0.89
- Ribonucleoprotein & translation · correlation 0.81
- Calcium Handling Contractile · correlation 0.80
- Actin remodeling · correlation 0.76
- SMC Phenotype Regulation · correlation 0.74
- Costameric cytoskeleton · correlation 0.74
- SMC contractile apparatus · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.