OxPhos & proteasome
Gene co-expression module in Smooth muscle cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
Dominated by nuclear-encoded respiratory chain subunits (NDUFA11, NDUFB2, NDUFB9, COX5B, CHCHD2) and mitochondrial redox proteins (PARK7, PRDX5), tightly co-expressed with the ubiquitin-proteasome system (SEM1/SHFM1, PSMC5, NEDD8, SKP1). This is the classic high-expression OxPhos/proteostasis energy-capacity module; uniform expression across subsets excludes contamination. It is the metabolic counterpart of the translation module M123 and the generic maintenance module M115 in this neighborhood.
Genes
CD151, CHCHD2, COX5B, EID1, NDUFA11, NDUFB2, NDUFB9, NEDD8, PARK7, PRDX5, PSMC5, SAP18, SDC2, SEM1, SKP1, SPCS1, YWHAQ
Most correlated modules
- Post-translational regulators · correlation 0.91
- Ribonucleoprotein & translation · correlation 0.88
- Generic maintenance transcripts · correlation 0.86
- SMC contractile apparatus · correlation 0.85
- Calcium Handling Contractile · correlation 0.85
- Actin remodeling · correlation 0.82
- Translation elongation housekeeping · correlation 0.82
- MHC-I antigen presentation · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.