Glucocorticoid Metallothionein Response
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Unambiguous dual signature: metallothionein cluster (MT2A, MT1X, MT1E, MT1M) for metal/oxidative stress buffering, together with the canonical glucocorticoid-receptor target set FKBP5, ZBTB16 (PLZF), TSC22D1, PNRC1, ZFAND5, and the C/EBP stress transcription factors CEBPD and CEBPB. This is the classic GC/stress-hormone-responsive program frequently seen in tissue SMC and fibroblasts, and it is the only module in this neighborhood with a discrete regulatory (rather than housekeeping-abundance) identity — its correlation with the housekeeping neighbors likely reflects shared per-cell transcript-capture variation.
Genes
CEBPB, CEBPD, FKBP5, MT1E, MT1M, MT1X, MT2A, PNRC1, TSC22D1, ZBTB16, ZFAND5, ZNF703
Most correlated modules
- Basal Maintenance Genes · correlation 0.82
- Ubiquitous Housekeeping Transcripts · correlation 0.82
- Myogenic Cytoskeletal Program · correlation 0.80
- Contractile SMC Identity · correlation 0.78
- Pericyte Notch Identity · correlation 0.78
- Calcium Handling Contractile · correlation 0.77
- Oxidative Muscle Metabolism · correlation 0.76
- Translation elongation housekeeping · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.