Fibroblast Matrisome
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
PLTP, FBLN1, ADAMDEC1, PROCR, LTBP4, NR2F1 and RGS10 constitute a fibroblast/adventitial-type matrisome and niche signature; ADAMDEC1 and PLTP mark colonic lamina propria/inflammatory fibroblasts and PROCR/NR2F1 mark adventitial progenitor-like mesenchyme. Expression is low (9% detection) and uniform, so part of the signal may reflect ambient fibroblast RNA, but strong coherence and the presence of structural matrix genes (FBLN1, LTBP4) argue for a genuine fibroblast-like matrisome state shared with the neighboring ECM modules M27 and M108.
Genes
ADAMDEC1, EMP1, FBLN1, LTBP4, NR2F1, PLTP, PROCR, RGS10, S100A10, UBE2E3
Most correlated modules
- Wnt-Hedgehog Niche · correlation 0.91
- Matrisome Regulators · correlation 0.85
- Lysosomal-secretory processing · correlation 0.84
- Adhesion Activation · correlation 0.84
- Collagen Biosynthesis · correlation 0.76
- Costameric cytoskeleton · correlation 0.73
- Generic maintenance transcripts · correlation 0.64
- SMC Phenotype Regulation · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.