Adhesion Activation
Gene co-expression module in Smooth muscle cells
| Category | Migration & adhesion |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hubs ANXA2, LAMC1, CD44, TGM2, LGALS3/LGALS3BP, FHL2 and EMP-like membrane genes define the classic activated/migratory mesenchymal surface program: annexin A2-S100 plasminogen-activation machinery, hyaluronan receptor CD44, galectin-3 adhesion/matrix crosslinking, transglutaminase-2 matrix stabilization and FHL2 mechano-transduction. Together with basement-membrane laminin gamma-1 this reads as a matrix-adhesion/activation state accompanying the collagen-synthetic neighbors (M108), not a contraction or contamination signature.
Genes
ANXA2, ATP1B3, CAPNS1, CD44, CYBRD1, FHL2, LAMC1, LGALS3, LGALS3BP, NUCB1, SERPINF1, TGM2
Most correlated modules
- Lysosomal-secretory processing · correlation 0.87
- Non-muscle Actomyosin · correlation 0.85
- Fibroblast Matrisome · correlation 0.84
- Matrisome Regulators · correlation 0.82
- Collagen Biosynthesis · correlation 0.82
- Wnt-Hedgehog Niche · correlation 0.81
- Costameric cytoskeleton · correlation 0.77
- Generic maintenance transcripts · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.