Microfibril ECM Assembly
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
A tightly co-regulated (core coherence) matrix/adhesion module dominated by elastic-fiber and basement-membrane components: FBN2 and THSD4 (ADAMTSL6, fibrillin microfibril assembly), NID1 (nidogen, BM crosslinker), SPON1 (F-spondin), SERPINE2 (protease nexin-1, matrix protease inhibitor), ITGA9 (integrin receptor for tenascin/osteopontin), NEO1 and ADAM28. PROM1 and SYT10 are peripheral markers of a distinct low-abundance mesenchymal subpopulation. Very low detection suggests a rare sub-state, but the program is clearly microfibril/ECM assembly, complementing collagen-centric M119 and crosslinking M24.
Genes
ADAM28, FBN2, ITGA9, NEO1, NID1, PROM1, PSD3, SERPINE2, SPON1, SYT10, THSD4
Most correlated modules
- FOXF2 Mesenchymal Patterning · correlation 0.93
- Matrix Crosslinking Activation · correlation 0.89
- Notch-TGFbeta Signaling · correlation 0.85
- Collagen-Laminin Deposition · correlation 0.84
- Synthetic Matrix Phenotype · correlation 0.83
- Neural Adhesion Program · correlation 0.82
- Lysosomal Glycoprotein Catabolism · correlation 0.76
- Matrix-integrin interaction · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.