Notch-TGFbeta Signaling
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Highest-expressed module in the batch, built around receptor/transcriptional modulators of mesenchymal quiescence: TGFBR3 (betaglycan, TGF-beta/BMP co-receptor), RBPJ and TLE4 (Notch transcriptional repression complex), MAF, EDIL3 (integrin-binding EGF-like ligand), tetraspanins CD9/CD81 (TGF-beta and integrin signalling platforms), with cytoskeletal FHL1 and GSN and the weakly-associated IEG JUND. This reads as a homeostatic Notch/TGF-beta signalling and differentiation-maintenance program of resting smooth muscle/fibroblast cells, complementing the matrix-synthetic neighbors (M119, M24) which represent the activated end of the same axis.
Genes
AHI1, CD81, CD9, CPED1, EDIL3, FHL1, GSN, JUND, MAF, RBPJ, TGFBR3, TLE4
Most correlated modules
- FOXF2 Mesenchymal Patterning · correlation 0.87
- Microfibril ECM Assembly · correlation 0.85
- Matrix-integrin interaction · correlation 0.84
- Lysosomal Glycoprotein Catabolism · correlation 0.83
- Integrin adhesion complex · correlation 0.78
- Matrisome Regulators · correlation 0.78
- Matrix Crosslinking Activation · correlation 0.77
- Collagen-Laminin Deposition · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.