RAMP1 — Receptor activity modifying protein 1
RAMP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAMP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Barrier Homeostasis migration & adhesion | AFDN, CD2AP, CLEC3B, ENPP2, IFNGR1, IL6R, ITGB4, JAM2 +11 more | View in SCUBA |
| Natural Killer cells | NK Cell Exhaustion Immune regulation | CEBPB, CEMIP2, DENND3, FMNL1, HAVCR2, IFNGR1, METRNL, PDE4D +3 more | View in SCUBA |
| Smooth muscle cells | SMC Ion Signaling Contractility | ANTXR2, ATP1B1, CDKN1C, CENPW, FAM83D, FXYD6, GAS1, KCNMA1 +12 more | View in SCUBA |
About the gene
| Chromosome | 2: 237858893-237912106 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Transport |
Function
Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene- related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB. Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.