Type I Interferon
Gene co-expression module in Smooth muscle cells
| Category | Inflammation |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
Textbook interferon-stimulated gene module: ISG15, IFI6, IFIT2, LY6E, BST2, IFITM1, STAT1, SP100, GBP4 plus immunoproteasome/antigen-presentation components PSMB8, PSME2 and HLA-F. Coherent and uniformly expressed, indicating a tissue-wide type I/II interferon exposure of the smooth muscle cells; its correlation with the chemokine module M104 reflects a shared inflammatory microenvironment.
Genes
BST2, GBP4, HLA-F, IFI6, IFIT2, IFITM1, ISG15, LY6E, PSMB8, PSME2, SP100, STAT1
Most correlated modules
- BMP-ID3 Matricellular · correlation 0.67
- IFN-gamma/NF-kB Response · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.