Endolysosomal Trafficking
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hubs are ubiquitous membrane-trafficking and endolysosomal genes: ARPC3 (Arp2/3 actin branching at endosomes), RAB5C (early endosome), RABAC1/PRA1 (prenylated Rab acceptor), LAMTOR1 (lysosomal Ragulator), NDFIP1 (Nedd4 adaptor on endosomes), TMEM50A, CD164 (endolysosomal sialomucin), FKBP1A, IFITM3 (endosomal membrane protein). Uniform expression, no subset enrichment, low-to-moderate levels — a basal vesicular trafficking/membrane housekeeping program. Neighboring M85 (translocon/proteostasis) and M71 (ubiquitin-autophagy) reinforce a shared protein-handling/degradative compartment neighborhood; IFITM3 here is a trafficking-associated member, not evidence of an interferon program (no ISG partners).
Genes
ARPC3, CD164, FKBP1A, IFITM3, LAMTOR1, NDFIP1, RAB5C, RABAC1, TMEM50A
Most correlated modules
- Translocon & Proteostasis · correlation 0.89
- Proteasome And Translation · correlation 0.86
- Actin Dynamics Housekeeping · correlation 0.84
- Mitochondrial Housekeeping · correlation 0.84
- Ubiquitous Housekeeping Transcripts · correlation 0.82
- Rho GTPase Housekeeping · correlation 0.80
- Atrophy Proteolysis Program · correlation 0.80
- Basal Metabolic Housekeeping · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.