Activated Myofibroblast
Gene co-expression module in Smooth muscle cells
| Category | Activation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hubs SERPING1 (complement C1-inhibitor, IFN/inflammation-inducible), IGFBP4, NNMT, TGFBI and IFI16 with SULF1, TNFRSF1A and CNN3/TPM4 describe an activated, matrix-modifying myofibroblast/fibromyocyte state rather than a contractile SMC program. SULF1 and TGFBI are TGF-beta target matricellular genes, NNMT a metabolic marker of activated stroma, and IFI16/TNFRSF1A add a cytokine-sensing flavor consistent with its neighbor M69 (IFN/NF-kB) and M107 (ER-secretory/OSMR). SSR4/LAPTM4B reflect the increased secretory load of this state.
Genes
CNN3, EPHX1, IFI16, IGFBP4, LAPTM4B, NNMT, SERPING1, SSR4, SULF1, TGFBI, TNFRSF1A, TPM4
Most correlated modules
- ER Chaperone/UPR · correlation 0.84
- Endolysosomal Trafficking · correlation 0.79
- BMP-ID3 Matricellular · correlation 0.77
- Non-muscle Actomyosin · correlation 0.76
- ER-Golgi Secretory Pathway · correlation 0.76
- Mesenchymal Adhesion Program · correlation 0.74
- ER Secretory Trafficking · correlation 0.74
- Atrophy Proteolysis Program · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.