Proteasome And Translation
Gene co-expression module in Smooth muscle cells
| Category | Protein processing & ER |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Dominated by proteasome subunits/activator (PSMA4, PSMB3, PSME1) together with the translation initiation machinery (EIF4A1, EIF2S2), spliceosomal SNRPE, chromatin factor MORF4L1, glycolytic ENO1, mitochondrial phosphate carrier SLC25A3 and ANXA5. This is the classic cytosolic protein synthesis/degradation homeostasis axis. Uniform expression across all subsets with no disease skew argues for a constitutive proteostasis program rather than a stress response (no HSPs, no immediate-early genes). Neighbors M99 (PSMB1) and M111 also carry proteasome/ribosome-adjacent members, confirming a shared proteostasis/housekeeping neighborhood. RBM3 is the only cold-shock/stress-related member and shows moderate membership.
Genes
ANXA5, EIF2S2, EIF4A1, ENO1, MORF4L1, PSMA4, PSMB3, PSME1, RBM3, SLC25A3, SNRPE
Most correlated modules
- Actin Dynamics Housekeeping · correlation 0.88
- Rho GTPase Housekeeping · correlation 0.87
- Membrane Protein Turnover · correlation 0.86
- Endolysosomal Trafficking · correlation 0.86
- Translocon & Proteostasis · correlation 0.85
- Sparse Mitoribosomal Housekeeping · correlation 0.82
- mRNA Splicing Factors · correlation 0.79
- Respiratory Chain Subunits · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.