Sparse Mitoribosomal Housekeeping
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
Lowest expression and detection in the batch (0.41 mean, 28% positive) with only moderate coherence and several weak-membership hubs — a hallmark of a sparse co-detection module. Content is a grab-bag of low-abundance maintenance genes: mitoribosomal subunits (MRPL32, MRPL41, MRPS7) and NDUFA5 (complex I) give a mitochondrial biogenesis flavor, mixed with ER/Golgi traffic (ERGIC3, SCPEP1, VKORC1, LEPROT, SMAP2), RNA-binding factors (RBM42, SNRPB2) and adhesion/signaling genes (CTNNA1, CIB1, CEP63, FBXO17). No lineage-specific markers and no subset enrichment, so contamination is unlikely; it behaves as a generic low-expression housekeeping/mitoribosome module correlated with the other ubiquitous-gene modules in this neighborhood (M99, M57, M111, M84).
Genes
CEP63, CIB1, CTNNA1, ERGIC3, FBXO17, LEPROT, MRPL32, MRPL41, MRPS7, NDUFA5, RBM42, SCPEP1, SMAP2, SNRPB2, VKORC1
Most correlated modules
- Proteasome And Translation · correlation 0.82
- Rho GTPase Housekeeping · correlation 0.78
- SMC focal adhesion · correlation 0.73
- Actin Dynamics Housekeeping · correlation 0.73
- Membrane Protein Turnover · correlation 0.72
- hnRNP & Proteasome · correlation 0.68
- MHC-I antigen presentation · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.