Translocon & Proteostasis
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes are small, ubiquitously expressed housekeeping transcripts centered on the ER translocon/membrane insertion machinery (SEC61G, TMEM258, TMEM147), translation and RNA modification (EIF3F, NOP10, SUB1), proteasome (PSMA1), chaperone (ST13), vesicle coat (CLTA) and v-ATPase (ATP6V0E1). No lineage-specific markers, uniform detection across subsets and modest expression — a generic proteostasis/biosynthetic housekeeping axis rather than a smooth-muscle program. Its neighbors M75 (trafficking housekeeping) and M71 (proteolysis) share the same general 'basal cell-maintenance' co-expression neighborhood, supporting a housekeeping interpretation rather than contamination.
Genes
ATP6V0E1, CLTA, EIF3F, NOP10, NPC2, PSMA1, SEC61G, ST13, SUB1, TMEM147, TMEM258
Most correlated modules
- Endolysosomal Trafficking · correlation 0.89
- Proteasome And Translation · correlation 0.85
- Mitochondrial Housekeeping · correlation 0.84
- Actin Dynamics Housekeeping · correlation 0.84
- Respiratory Chain Subunits · correlation 0.83
- OxPhos & Translation · correlation 0.83
- Translation elongation housekeeping · correlation 0.82
- Basal Metabolic Housekeeping · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.