mRNA Splicing Factors
Gene co-expression module in Smooth muscle cells
| Category | RNA processing & translation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Dominated by RNA-binding and spliceosomal proteins (PCBP1, PCBP2, SNRPF, SF3B5, HNRNPA0, RBMX), chromatin/histone chaperones (NAP1L1, RBBP7) with a minor ER-stress/ISR component (ATF4, TMBIM6). Uniform, no lineage skew. Neighboring M63 shows the same hnRNP core, confirming an mRNA-processing axis within this housekeeping neighborhood.
Genes
ATF4, BEX3, CLIC4, COX20, HNRNPA0, NAP1L1, NDUFA6, NME4, PCBP1, PCBP2, RBBP7, RBMX, RSU1, SF3B5, SNRPF, TMBIM6
Most correlated modules
- Respiratory Chain Subunits · correlation 0.86
- Actin Dynamics Housekeeping · correlation 0.86
- Membrane Protein Turnover · correlation 0.84
- Basal Metabolic Housekeeping · correlation 0.84
- Proliferative Biosynthesis · correlation 0.84
- OxPhos & Translation · correlation 0.82
- Basal metabolic housekeeping · correlation 0.82
- Mitochondrial Housekeeping · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.