Membrane Protein Turnover
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
A mixed set of broadly expressed membrane and maintenance genes: BSG/CD147 (chaperone for MCT lactate transporters), CAP1 (adenylyl-cyclase-associated actin regulator), SSR2 (ER translocon), ATP6AP2 (V-ATPase/renin receptor), UBE2N (ubiquitin conjugation), EI24, TCEAL9 and chromatin repressor CBX6. AXL and MFAP4 give a mild mesenchymal/stromal flavor (MFAP4 with weak membership, likely ambient/peripheral). Uniform, modest expression across subsets with no lineage-restricted marker set points to a baseline membrane/protein-turnover housekeeping program in smooth muscle cells rather than contamination or an activation state; fits the neighborhood of ubiquitous-gene modules (M99, M111, M57).
Genes
ATP6AP2, AXL, BSG, CAP1, CBX6, EI24, MFAP4, SSR2, TCEAL9, UBE2N
Most correlated modules
- Actin Dynamics Housekeeping · correlation 0.90
- Proteasome And Translation · correlation 0.86
- mRNA Splicing Factors · correlation 0.84
- Respiratory Chain Subunits · correlation 0.82
- Lysosomal Glycoprotein Catabolism · correlation 0.81
- Basal Metabolic Housekeeping · correlation 0.80
- Rho GTPase Housekeeping · correlation 0.79
- SMC focal adhesion · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.