SCUBA

RBM3 — RNA binding motif protein 3

RBM3 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RBM3's module in each cell type

Cell typeModuleShares the module with
EndothelialSpliceosome snRNP Assembly
RNA processing & translation
BAX, CBX3, CCT2, CCT4, EIF3I, FGFR1, HNRNPAB, HNRNPC +6 moreView in SCUBA
EnterocytesTransit-amplifying progenitor
Epithelial development
CCND2, CLINT1, EHF, ELOVL6, HSD17B12, MSI2, PKP2, SLC38A1View in SCUBA
FibroblastsActin Cytoskeleton
Cytoskeletal
ACTB, CAPZA2, CFL1, CMTM6, COX8A, KIF5B, MORF4L2, NDUFS5 +6 moreView in SCUBA
Gamma-delta T cellsChromatin-Splicing Regulation
DNA/chromatin regulation
ANKRD11, BOD1L1, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MED10 +13 more
Glial cellsER Stress Response
Stress
ANXA1, ARF4, CSNK1A1, HSPA5, KRT10, RAB32, SERP1, SET +4 moreView in SCUBA
Hematopoietic progenitor cellsBiosynthetic Housekeeping
Housekeeping
BZW2, CHST12, CREG1, EEF1B2, FBL, HNRNPA1, HSP90AB1, IMPDH2 +7 more
MacrophagesRAS-MAPK Signaling
Housekeeping
ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 moreView in SCUBA
Mucosal-associated invariant T cellTGF-beta Response
Immune regulation
ABCA1, ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1 +21 more
Smooth muscle cellsProteasome And Translation
Protein processing & ER
ANXA5, EIF2S2, EIF4A1, ENO1, MORF4L1, PSMA4, PSMB3, PSME1 +2 moreView in SCUBA

About the gene

SynonymsIS1-RNPL
ChromosomeX: 48574449-48581162
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionRNA-binding
Biological processStress response

Function

Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.