FOXC-PRDM16 Program
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
A low-abundance but tightly coherent module built around developmental transcription factors FOXC1, FOXC2, PRDM16 and SOX6 together with muscle-specialization genes (CARNS1 carnosine synthase, CKMT2 sarcomeric mitochondrial creatine kinase, SNTB1 syntrophin of the dystrophin-glycoprotein complex, MYO1D) and mural/matrix genes ITIH3, SUSD5, CMKLR1. The FOXC1/FOXC2–PRDM16–SOX6 axis specifies mural/arteriolar and muscle lineage identity, so this is best read as a rare transcription-factor-driven SMC subtype program rather than a metabolic or stress state; it sits alongside the other subtype/identity modules (M36, M116) in this neighborhood.
Genes
ARHGEF10L, CARNS1, CKMT2, CMKLR1, DUSP26, FOXC1, FOXC2, ITIH3, MYO1D, PRDM16, SNTB1, SOX6, SUSD5
Most correlated modules
- Mural/Pericyte Identity · correlation 0.83
- Vascular SMC Identity · correlation 0.82
- Oxidative Muscle Metabolism · correlation 0.79
- Wnt-Notch Modulation · correlation 0.78
- Vasoconstrictor Signaling · correlation 0.76
- Pericyte Basement Membrane · correlation 0.76
- Contractile SMC Identity · correlation 0.75
- Arteriolar Mural Cells · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.