Oxidative Muscle Metabolism
Gene co-expression module in Smooth muscle cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hubs COX7A1 (muscle-specific cytochrome c oxidase subunit) and NDUFB7 (complex I) anchor an oxidative-phosphorylation core, combined with caveolar/plasma-membrane components of differentiated smooth muscle (CAV2, FXYD1/phospholemman, MFGE8), redox handling (MGST3), the cardiac/muscle apoptosis repressor NOL3, and LIM-domain adaptors CRIP2/WTIP. This represents the oxidative-metabolic, caveolae-rich state of mature contractile SMC, complementing the mural identity module M36 and the actomyosin module M44 in the same neighborhood (shared reliance on COX muscle isoforms with M44's COX6A2).
Genes
CAV2, COX7A1, CRIP2, FXYD1, HCFC1R1, LGR6, MFGE8, MGST3, NDUFB7, NOL3, WTIP
Most correlated modules
- Vascular SMC Identity · correlation 0.93
- Myogenic Cytoskeletal Program · correlation 0.89
- Basal Maintenance Genes · correlation 0.85
- Actomyosin Regulation · correlation 0.84
- Wnt-Notch Modulation · correlation 0.82
- OXPHOS Complex I · correlation 0.80
- FOXC-PRDM16 Program · correlation 0.79
- Contractile SMC Identity · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.