Wnt-Notch Modulation
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
The module is dominated by developmental signaling modulators: FRZB (secreted Wnt/Frizzled antagonist), NRIP2 (TCF/LEF-Wnt repressor), LBH (Wnt-responsive transcription cofactor), HES4 (Notch effector bHLH), plus PHLDA2 (imprinted growth suppressor), SERPINI1 (neuroserpin), NRGN and NET1 (RhoGEF linking to actin/SRF). This combination reads as a Wnt/Notch-modulated positional or subtype program in mural cells rather than a stress or metabolic module, distinguishing it from its OxPhos/contractile neighbors while sharing the SMC differentiation axis (HEY2 in M52 is also a Notch target).
Genes
CLMN, FRZB, HES4, LBH, MAP3K7CL, NET1, NRGN, NRIP2, PHLDA2, SERPINI1
Most correlated modules
- Vascular SMC Identity · correlation 0.92
- Pericyte Signature · correlation 0.91
- Mural/Pericyte Identity · correlation 0.90
- Actomyosin Regulation · correlation 0.87
- Oxidative Muscle Metabolism · correlation 0.82
- Arteriolar Mural Cells · correlation 0.80
- FOXC-PRDM16 Program · correlation 0.78
- Vasoconstrictor Signaling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.