Vasoconstrictor Signaling
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
EDNRA (endothelin receptor A, the principal vasoconstrictor receptor of vascular SMC), SPARCL1, CSRP2 (SMC actin-associated LIM protein), ARHGAP29 (RhoA GAP controlling actomyosin tone), PTP4A3 and the glucocorticoid receptor NR3C1 together describe a vascular SMC tone/receptor-signaling state rather than a structural contractile apparatus module. CDK18, NUDT4, ATP10A, BBX and RNF152 are signaling/peripheral members. Fits the mural neighborhood (M100/M32) as the receptor-signaling arm of vascular contractility.
Genes
ARHGAP29, ATP10A, BBX, CDK18, CSRP2, EDNRA, GPAT2, NR3C1, NUDT4, PCDH1, PTP4A3, RNF152, SPARCL1
Most correlated modules
- Mural/Pericyte Identity · correlation 0.89
- Arteriolar Mural Cells · correlation 0.88
- Secondary Response Genes · correlation 0.85
- Vascular Tone Signaling · correlation 0.81
- Pericyte Basement Membrane · correlation 0.79
- Wnt-Notch Modulation · correlation 0.78
- FOXC-PRDM16 Program · correlation 0.76
- Contractile SMC Identity · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.