RAB5C — RAB5C, member RAS oncogene family
RAB5C belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB5C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing & Trafficking RNA processing & translation | ARF1, ARL6IP1, ARRDC2, B3GNT2, C17orf49, CCDC12, CWC15, DDX39A +19 more | |
| Innate lymphoid cells | Mitochondrial Lysosomal Housekeeping Mitochondrial & OxPhos | BTF3L4, C14orf119, EMC6, ETFA, IER3IP1, JTB, LAMP1, MRPL14 +7 more | View in SCUBA |
| Macrophages | Protein Homeostasis Mixed Housekeeping | ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more | View in SCUBA |
| Smooth muscle cells | Endolysosomal Trafficking Housekeeping | ARPC3, CD164, FKBP1A, IFITM3, LAMTOR1, NDFIP1, RABAC1, TMEM50A | View in SCUBA |
About the gene
| Synonyms | RAB5CL, RABL |
|---|---|
| Chromosome | 17: 42124978-42155044 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Hydrolase |
| Biological process | Protein transport, Transport |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.