Atrophy Proteolysis Program
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Top genes form a coherent FOXO/ubiquitin-proteasome-autophagy stress program: FBXO32 (atrogin-1, the canonical muscle atrophy E3 ligase), SQSTM1/p62 (autophagy receptor and oxidative-stress/NRF2 target), UBE2B (ubiquitin conjugation), SERINC3, ARL6IP5 (JWA, glutamate transport/oxidative stress), GLUL (glutamine synthetase, catabolic/atrophy marker), CTDSP2 and FOXP1 (transcriptional regulators). In smooth muscle this corresponds to a catabolic/atrophy-like proteolytic stress response rather than generic housekeeping, distinguishing it from its housekeeping neighbors M85 and M75 which share the broader protein-degradation compartment context.
Genes
ARL6IP5, CTDSP2, FBXO32, FOXP1, GLUL, SERINC3, SQSTM1, UBE2B
Most correlated modules
- Translocon & Proteostasis · correlation 0.80
- Endolysosomal Trafficking · correlation 0.80
- hnRNP & Proteasome · correlation 0.75
- Activated Myofibroblast · correlation 0.74
- IFN-gamma/NF-kB Response · correlation 0.68
- KLF6/ZNF24 regulators · correlation 0.67
- Chaperonin heat-shock · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.