Actin remodeling
Gene co-expression module in Smooth muscle cells
| Category | Cytoskeletal |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
The two dominant hubs are actin-cytoskeletal effectors — PLS3 (plastin-3, actin bundling) and ARPC5 (Arp2/3 complex) — supported by CALM1 (calmodulin, actomyosin/Ca regulation), KTN1 (kinetochore/ER-microtubule linker) and GNAS. The remaining genes (SERBP1, HNRNPM, GADD45GIP1) are RNA-binding housekeeping transcripts, making this a small mixed module whose identity is driven by the actin arm. Its co-expression with the cytoskeletal/adhesion module M23 and generic maintenance modules supports an actin-remodeling program on a housekeeping background.
Genes
ARPC5, CALM1, GADD45GIP1, GNAS, HNRNPM, KTN1, PLS3, SERBP1
Most correlated modules
- Generic maintenance transcripts · correlation 0.84
- OxPhos & proteasome · correlation 0.82
- Ribonucleoprotein & translation · correlation 0.80
- Post-translational regulators · correlation 0.76
- SMC Phenotype Regulation · correlation 0.74
- Non-muscle Actomyosin · correlation 0.68
- Costameric cytoskeleton · correlation 0.67
- Vascular Tone Signaling · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.