Vascular Tone Signaling
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
PDE3A (cGMP-inhibited phosphodiesterase controlling SMC relaxation), ADCY3, ROCK1 (Rho-kinase, myosin phosphatase inhibition) and EPS8 (actin capping/bundling) constitute a cyclic-nucleotide/Rho tone-regulation axis, framed by the mural transcription factors EPAS1 (HIF2A) and NR2F2 (COUP-TFII) that specify venous/perivascular mural identity. PTEN, CPEB4, TIMP3, DBI are moderately-associated peripheral genes, consistent with the 'strong' but not core coherence. Neighbors M66 (EDNRA vasoconstrictor signaling) reinforce a vascular tone-signaling interpretation.
Genes
ADCY3, CPEB4, CYSTM1, DBI, EPAS1, EPS8, IER5L, NR2F2, PDE3A, PLEKHH3, PTEN, ROCK1, SLCO3A1, TIMP3
Most correlated modules
- Mural/Pericyte Identity · correlation 0.82
- Vasoconstrictor Signaling · correlation 0.81
- Arteriolar Mural Cells · correlation 0.75
- Capillary Pericyte · correlation 0.71
- Pericyte Basement Membrane · correlation 0.70
- Secondary Response Genes · correlation 0.68
- Wnt-Notch Modulation · correlation 0.68
- Pericyte Signature · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.