Ribonucleoprotein & translation
Gene co-expression module in Smooth muscle cells
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
Hubs combine the translation/ribonucleoprotein machinery (HNRNPC, NACA, EEF1B2, SNRPG, NCL, HMGB1) with abundant lysosomal/redox housekeeping proteins (PSAP, LAPTM4A, PRDX6, CYB5R3) and the signal peptidase SEC11A. The RNA-binding/translation arm dominates by membership strength, and the high mean expression/detection indicates a highly expressed biosynthetic core program. Neighbors M110 and M115 carry the complementary proteasome/OxPhos maintenance load, consistent with a shared cellular biosynthetic-capacity axis.
Genes
CRYAB, CYB5R3, EEF1B2, HMGB1, HNRNPC, LAPTM4A, MAGED2, NACA, NCL, PRDX6, PSAP, SEC11A, SNRPG, TMEM59
Most correlated modules
- OxPhos & proteasome · correlation 0.88
- Generic maintenance transcripts · correlation 0.86
- Translation elongation housekeeping · correlation 0.83
- Post-translational regulators · correlation 0.81
- Actin remodeling · correlation 0.80
- Non-muscle Actomyosin · correlation 0.78
- SMC contractile apparatus · correlation 0.71
- Calcium Handling Contractile · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.