Non-muscle Actomyosin
Gene co-expression module in Smooth muscle cells
| Category | Cytoskeletal |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Non-muscle myosin/actomyosin core (MYH9, MYL12A, MYL12B, DYNLL1) together with adhesion and mechanotransduction genes (LIMS1/PINCH, FILIP1L, S100A11, CLIC1, CD63) and secreted remodeling factors (TIMP1, C1R). This is a non-muscle contractile/adhesive cytoskeletal program typical of synthetic-phenotype SMC/myofibroblasts, complementary to the activated state in M117 and the secretory modules M107/M64. LDHA/CAST are peripheral (glycolytic/protease-inhibitory) members.
Genes
C1R, CAST, CD63, CLIC1, DYNLL1, FILIP1L, LDHA, LIMS1, MYH9, MYL12A, MYL12B, S100A11, TIMP1
Most correlated modules
- Adhesion Activation · correlation 0.85
- Ribonucleoprotein & translation · correlation 0.78
- Activated Myofibroblast · correlation 0.76
- Collagen Biosynthesis · correlation 0.72
- Lysosomal-secretory processing · correlation 0.69
- Generic maintenance transcripts · correlation 0.69
- OxPhos & proteasome · correlation 0.68
- MHC-I antigen presentation · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.